It happened around 11:30 a.m. Thursday on the 1100 block of West Somerset Street.
Investigators said Zylah McQueen, 4, was shot once in the arm, but the bullet went through her chest and stomach.
She was taken to the hospital in stable condition.
A second victim, her cousin, Jerry Gooden, 32, was shot twice. He was taken to the hospital where he was pronounced dead.
Police said no arrests have been made as they continue their investigation.