It happened just after 5 a.m. on the 3400 block of North 11th Street.
Officials said a 40-year-old woman was shot in the head, body and buttocks.
The victim was transported to Temple University Hospital where she died a short time later.
Investigators said they found 3 shell casings at the scene.
There is no word yet on what sparked the shooting.
No arrests have been made at this time.