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The shooting happened just before 1 a.m. on the 1300 block of North 10th Street.
Police said two victims ran inside a home after they were wounded.
The 17-year-old girl was listed in critical condition.
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A 23-year-old man was shot several times and was listed in stable condition.
Authorities said a 31-year-old man later turned up at Temple University Hospital with gunshot wounds to his leg.
Police said dozens of juveniles were seen fleeing the scene as they arrived.
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