It happened around 5 a.m. in the northbound lanes just past the Quakertown exit.
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Police said the man who was struck is critically injured and medics and rescue crews are at the scene.
NB lanes of Northeast Extension shut down after pedestrian struck
All northbound lanes were are closed for approximately 5 hours as police investigated the incident.
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Motorists were advised to avoid the area as there were major traffic delays.