Firefighters raced to the 5200 block of C Street, pulling a burned 17-year-old boy from the home.
Action News was also told the blaze was so intense that a 44-year-old man jumped from a second-story window to escape the flames and smoke, injuring his leg.
Two women, ages 48 and 65, are also being treated for burns and smoke inhalation
The cause of the fire is still under investigation.