It happened just before 10 a.m. Sunday on the 6200 block of Lansdowne Avenue in front of the Felton Mini Mart.
Police said the 28-year-old male suspect stabbed a 26-year-old man several times in the face.
The victim was taken to Penn Presbyterian Medical Center where he was pronounced dead.
Police said the suspect was arrested hours later after he walked into the same hospital with lacerations to his hands.