Police say the driver lost control around 8 a.m. Tuesday, causing the big rig to flip on its side.
It happened on the ramp from Route 420 to I-95 North in Tinicum Township.
There was no immediate word on whether the driver was seriously hurt.
The crash completely shut down the ramp as police investigated and crews worked to right the truck.
The ramp was reopened shortly before 12:30 a.m. Tuesday.