The damage is so extensive that fire officials have not even been able to go inside as they search for a cause.
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The blast happened just before 7 a.m. Friday morning on the unit block of Stump Lane in North Heidelberg Township.
Video from Chopper 6 showed one wall of the home was missing, with significant damage around the rest of the building.
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The man inside was able to crawl out of the debris and walk to a neighbor's house for help.
Investigators are trying to figure out what caused the explosion, but natural gas is not supplied to that area, instead propane gas is used for heat.