It happened around 2:30 p.m. Sunday on Rt. 412 in Nockamixon Township in front of Palisades High School.
According to authorities, Stephen Yothers and Vincent Nielsen, both 54, were killed when they were struck by a driver while riding their motorcycles.
They were pronounced dead at the scene.
Authorities say an 18-year-old woman driving a Ford pickup truck went off the road and crashed into the men when she tried to regain control.
She was taken to an area hospital and treated for minor injuries.