Officers used bull horns to communicate with a person of interest during a standoff a house in the 1200 block of East 4th Street.
Chief Mark Diluzio said the 4th Street standoff is part of an investigation into a shooting that happened around 3 p.m. about a mile away in the 800 block of Argus Court.
Shooting investigation ends in stand-off in Bethlehem
Investigators said the shooting started as an argument that spun out of control.
The victim was taken to the hospital with a police escort.
Two men were eventually taken into custody.
Officials said the victim is in serious condition.