It happened after 8 p.m. Friday on the unit block of East 21st Street.
Someone fired shots from a vehicle as it traveled east on East 21st Street from Edgmont Avenue.
A 21-year-old man was shot four times, but is hospitalized in stable condition.
The three other victims were taken to the hospital, but their conditions were not released.
A fifth person was hurt by flying glass while sitting in a car, sustaining some facial injuries.
Police are looking for the shooter.
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