The collision happened at 9:30 a.m. Tuesday.
Action News is told a tractor-trailer collided with another vehicle.
At least one person was hurt. The extent of injuries to that person was not clear.
Traffic on I-476 South was said to be at a virtual standstill, with two right lanes blocked between the exits for Norristown and I-76.
Lane restrictions were still in effect more than an hour after the crash.
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