Investigators said a Camaro and a cement truck collided shortly before 10 a.m. on Limekiln Pike near the intersection of Upper State Road.
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Two other vehicles were also involved.
The driver of the Camaro has serious injuries and is being treated at the hospital.
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There is no word yet as to when exactly this section of Limekiln Pike will reopen.
Truck, car collide in Warrington; 1 reported trapped
Police are investigating what led to the crash.