Neighbors on King Avenue in Folcroft called for help Sunday evening when they saw smoke.
Fire crews extinguished the flames then went inside the house.
That's when they found a female victim and pulled her out.
First responders performed CPR and took her to Crozer Chester Medical Center.
There's no word on her age or condition.
An arson-sniffing dog checked the scene, but officials are still trying to figure out what caused the fire.
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