The wreck happened in the southbound lanes around 4 p.m. between Lehigh Valley and Quakertown.
Police say a car and box truck collided, and the car overturned.
Two people in the car were taken to the hospital with non-life-threatening injuries.
All southbound lanes were shut down after the crash, but by 7:30 p.m. the scene was cleared.
No word on what led to the crash.
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