Investigators say five of the six suspects are charged with drug delivery resulting in death.
A 6th suspect, 52-year-old Kurt Espenship, is charged with involuntary manslaughter.
The arrests came as a result of a multi-agency investigation.
The victims range in age from 29 to 55.
"These 4 deaths are real-life Montco residents who were loved by family friends and whose death left a hole that will not be filled," said
Police are currently searching for Marquese Gaines.
The other five suspects were all taken into custody.