The crash happened before 6:30 a.m. Tuesday in the eastbound lanes approaching the Conshohocken Curve.
Video from Chopper 6 HD showed a five-vehicle pileup in the left lane.
There were no immediate reports of serious injuries.
Traffic was down to one lane for well over an hour as police investigated and crews worked to clean up a fuel spill and move the damaged vehicles.
Crash slows traffic on EB I-76
The backup extended for miles approaching the scene.
Delays were reported as far back as the Route 202 interchange in King of Prussia, Pa.
All lanes were finally reopened by 8 a.m.
There was no immediate word what caused the pileup.
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