The victim has been identified as 23-year-old Keith Allan Ream of Coatesville.
It happened around 11 p.m. Wednesday night in East Caln Township.
Authorities say Allan was traveling westbound in the eastbound lanes when he collided with a tractor-trailer.
Allan was ejected from his vehicle.
No other injuries were reported.
The eastbound Route 30 Bypass was closed as police investigated. It reopened around 8:30 a.m. Thursday.
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