It happened around 1 p.m. in the westbound lanes west of the Bensalem exit, Exit 351.
Action News is told the big rig was carrying steel coils when it collided with other vehicles and overturned.
There were no immediate reports of serious injuries.
All westbound lanes were shut down for several hours as crews worked to clear the debris and clean up a fuel spill that appears to have resulted from the crash.
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