It happened shortly before 6 a.m. Tuesday on Route 202 southbound near Matlack Street in West Chester.
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At one point, the right lane and off-ramp were blocked.
Northbound 202 was also jammed due to the responding emergency crews.
The crash involved a box truck and another vehicle.
There were reports of someone trapped in the wreckage, however, authorities have not confirmed that information at this time.
Crash on Route 202
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