It happened near Exit 351 in Bensalem, Bucks County.
State police confirmed one person died as a result of the crash. No further information has been released on the victim's identity.
The right lane of the turnpike and the westbound off-ramp at Exit 351 were temporarily closed after the crash, officials say.
All lanes were reopened just before 8 p.m.
Police have not provided any details on what may have led to the crash.