It happened around 10 a.m. in the 1000 block of West Lincoln Highway.
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The crash involved a pickup truck and another vehicle, both of which veered off the roadway.
One person died and two others were taken to the hospital.
Lincoln Highway was closed between First Avenue and Saint George's Street until about 3:15 p.m.
Chopper 6: Deadly crash in Valley Township, Pa.
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