It happened just before 12 a.m. near 45th and Chestnut streets.
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Police say a 44-year-old male driver was traveling northbound on 45th Street when he collided with a 26-year-old driver going eastbound on Chestnut Street.
The 44-year-old man was pronounced dead at the hospital.
The driver of the other vehicle was injured but is expected to survive.
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No charges have been filed at this time.
The driver who died from his injuries has not been identified.