The blaze broke out in the southbound lanes after 6 a.m. Friday near the Allegheny Avenue exit.
Video from a Sky 6 camera showed flames and heavy smoke fully engulfing the vehicle.
Several southbound lanes were blocked as crews worked to douse the flames.
There were no immediate reports of injuries.
Traffic was delayed from the Cottman Avenue exit to Allegheny for well over an hour due to the incident.
All lanes were back open and traffic moving again by 7:30 a.m.
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