Police say the suspect carjacked a vehicle on the 4200 block of Old York Road Thursday afternoon.
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The suspect was later spotted around 4:30 p.m. in the city's Fairhill neighborhood.
Officials say the suspect ultimately crashed at Mascher Street near Indiana Avenue while trying to elude police.
The view from Chopper 6 showed at least four vehicles damaged in the wreck.
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At least one person was taken to the hospital for non-life-threatening injuries.
The suspect has not been identified.