It happened at 3:20 a.m. Monday in the northbound outer lanes at Allengrove Street.
Police arrived to find a vehicle that had slammed into a tree.
Four people inside - the 19-year-old male driver, a 25-year-old man and two 21-year-old women - were taken Albert Einstein Medical Center.
There was no immediate word on their condition.
Investigators were working to determine what caused the driver to control.
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