It happened around 10:30 p.m. on Allegheny Avenue near Front Street in North Philadelphia.
Police released video of the wanted dirt bike rider.
Authorities say the rider was doing wheelies on the highway when the crash occurred.
The 17-year-old male was transported to Temple University Hospital and listed in extremely critical condition.
Anyone with information is asked to contact the Philadelphia Accident Investigation District at 215-685-3184.