It happened around 8:50 p.m. on the 2400 block of East Lehigh Avenue.
Police say the driver of a dark-colored sedan hit the pedestrian who was attempting to cross the street.
The victim, identified by police as a male, was rushed to an area hospital in extremely critical condition.
The driver was last seen fleeing west on Lehigh Avenue.
Investigators released an image of the vehicle, which had a temporary Pennsylvania tag #4183108.
Anyone with information is asked to call police at 215-686-TIPS.