It happened at 7 a.m. Friday at the intersection of North 6th and West Berks streets.
Action News is told the bus and a car collided, and the driver of the car left the scene.
The SEPTA driver and all five passengers on the bus were taken to Temple University Hospital to be treated for injuries described as minor.
Police are working to determine exactly what led to the crash and why the other driver left the scene.
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