The shooting happened at about 11:37 p.m. in the 2500 block of West Master Street.
Police said a 32-year-old man, who has since been identified as Kareem Killen, was shot multiple times. He was taken to Penn Presbyterian Medical Center where he died at about 12:15 a.m.
A 30-year-old man was shot in the back and right foot, police said. He was also taken to Penn Presbyterian Medical Center where he was listed in critical condition.
A third victim, a 32-year-old man, was shot in both legs and is in stable condition, police said.
No arrests have been made in this case. The investigation is ongoing.