It happened around 9 p.m. Monday on the 3000 block of Clifford Street near Montgomery Avenue.
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Police say that's where the victim, identified as 57-year-old Ralph Brodie, was found inside a home with a gunshot wound to the leg.
He was taken to Temple University Hospital where he died from his injuries.
No arrests have been made.
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There have been at least 503 homicides in the city this year, short of last year's total of 562.
But it is only the second time in the city's history that the homicide count has surpassed 500.
RELATED: Check the 6abc Neighborhood Safety Tracker