It happened around 11:30 p.m. Wednesday on the second floor of a home on the 2500 block of North Gratz Street.
Police say a 23-year-old man was shot in the head and died from his injures.
A 21-year-old man was shot in the shoulder.
An elderly woman was in a nearby bedroom, but was not injured.
Police say they know the identity of the shooter who fled from the scene.
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