It happened around 2:40 a.m. Friday on the 3100 block of Fontain Street.
Arriving fire crews were met with heavy flames coming from the first and second stories of a row home.
The injured woman suffered smoke inhalation; it is unclear at this time why the firefighter was hospitalized.
Crews gained control of the flames just after 3 a.m.
Investigators are working to determine how the fire started.
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