The shooting happened around 4:30 p.m. in the 2200 block of N. 7th Street.
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Police say the victims, Wahid Redmond, 31, and Keith Richardson, 29, were inside a blue Nissan Sentra.
They were both shot multiple times in the head and body, police said.
Both men were pronounced dead at the scene.
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A gun has been recovered, police say, but no arrests have been made.
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