It happened at 9:30 a.m. Thursday in the 4700 block of Meridian Street.
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Chopper 6 HD was overhead as firefighters battled the blaze in a 2-story home.
It took them over an hour to get the upper hand.
Rescuers took a woman to Aria-Jefferson Health Torresdale.
She is listed in critical condition.
Fire investigators were working to determine what sparked the blaze.
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