The fire broke out around 6 a.m. Friday on the 4000 block of Welsh Road, between Charles Street and Frankford Avenue, in Mayfair.
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Arriving crews were faced with a two-story home fully engulfed in flames.
Around 20 minutes into fighting the blaze, part of the home collapsed forcing firefighters to only work from the outside.
About 70 fire department members were called to the scene.
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It took crews more than half an hour to place the fire under control.
No injuries have been reported.
The cause of the fire is under investigation.