Pennsylvania State Police say it happened around 5:25 p.m. Saturday on northbound I-95 under the Ben Franklin Bridge.
Investigators say the biker lost control after hitting a pothole then a guardrail.
The 23-year-old victim from Collegeville, Pa. was taken to the hospital with severe head injuries.
Authorities say he later died of his injuries.
His identity has not been released.
Motorcyclist crashes after hitting pothole in Penn's Landing
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