It happened just before 6 a.m. Sunday morning on the 1200 block of Latimer Street.
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Police said a 37-year-old woman was sexually assaulted and robbed by an unknown black male wearing a black shirt and pants.
Police: Woman robbed, sexually assaulted in Center City
Police said the man drove away from the scene in a red vehicle with unknown Pennsylvania registration.
The woman was taken to the hospital where she in stable condition.
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Anyone with any information is asked to call police at 215-686-TIPS.