It happened around 4:10 p.m. at 18th and Master streets.
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Police say someone opened fire in a second floor bedroom.
A 24-year-old man was shot in the head. He was pronounced dead at the scene.
Police say a second victim showed up at Hahnemann University Hospital with gunshot wounds to the face, shoulder and chest.
Police say three males fled the scene on foot and remain at large.
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