The shooting happened shortly before 3 a.m. at the VIP Nightclub in the 3500 block of I Street.
Police say the two victims were in a car when the gunman opened fire.
The driver, a 21-year-old man, was shot in the face and is in critical condition.
The other man, a 26-year-old, was hit in the back. He was taken to the hospital by private auto.
There was no word on a description of the suspect.
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