The 52-year-old man's Audi Q5 collided with a Saturn SUV around 4:45 p.m. at 57th Street and Kingsessing Avenue.
Police say he may have been high on narcotics at the time of the accident.
An 11-year-old inside the other SUV was taken to Children's Hospital of Philadelphia. He is expected to make a full recovery.
The two adults in the SUV were also hospitalized with non-life threatening injuries.