It happened around 8:20 p.m. on the 700 block of Green Street.
Police say a 24-year-old woman was shot in the right leg and abdomen. She was transported to an area hospital where she's currently listed in critical but stable condition.
A 31-year-old man was also found suffering from a gunshot. He was transported to an area hospital where he later died.
Police say shots rang out around the same time, just blocks away, near 10th and Brown Street.
A 37-year-old woman suffered non-life threatening injuries after being shot in the foot.
No arrests have been made.
Anyone with any information is asked to call police at 215-686-TIPS.