It happened at 9:40 a.m. Wednesday at a construction site in the 200 block of South Broad Street.
Fire department officials say a man working on the 16th floor fell through to the 15th floor of a building.
The 30-year-old worker was taken to Thomas Jefferson University Hospital to be treated for a possible neck injury.
He was listed in stable condition.
The circumstances surrounding the fall were not immediately clear.
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