Police were called to the 2500 block of North 30th Street just after 6:30 p.m.
When officers arrived on the scene they found a 44-year-old man who had been stabbed in the neck.
He was rushed to Temple University Hospital where he died a short time later.
Police say it was the result of a domestic dispute but have not made any arrests.
Anyone with information is asked to call police at 215-686-TIPS.