The first happened just after 8 p.m. in the city's Tacony section.
Police say a 26-year-old Quran Justice, was shot multiple times in the 7400 block of State Road.
He was taken to Jefferson - Torresdale Hospital where he succumbed to injuries, police said.
Then, about an hour later, police say a man in Frankford was shot in the head.
The shooting happened in the 4500 block of Frankford Avenue.
The victim, a man in his 20s, died.
No arrests have been made in either shooting.