The first happened in the city's Germantown section just before 4:30 p.m.
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According to police, A 21-year-old was shot multiple times in the 100 block of West Chelten Avenue.
Police took him to the hospital where he later died.
A few hours later in the Cobbs Creek section, a 20-year-old man was shot and killed, police said.
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The shooting happened just after 7:30 p.m., in the 5800 block of Catherine Street.
No arrests have been made in either shooting.
RELATED: Check the 6abc Neighborhood Safety Tracker