Police were called to South Ithan Street and Chester Avenue around 4:15 a.m. Friday.
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Arriving officers found a 52-year-old man and a woman shot. Police did not say the woman's age.
They also discovered a gun near the two victims and a blood trail. Police followed it to a nearby home.
Once inside, officers found two more men, ages 26 and 23. suffering from gunshot wounds.
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Police also found a handgun and cocaine inside the home.
The woman is listed in critical condition. The three men are stable.
No arrests have been made.