It happened around 8:30 p.m. on the 4800 block of Frankford Avenue in the Frankford section of the city.
Arriving officers found a 40-year-old man lying on the floor of the restaurant, suffering from a gunshot wound to the chest.
According to Philadelphia Chief Inspector Scott Small, the gunman walked up to the victim and fired multiple shots just after he picked up his food.
"We know at least three shots were fired because we found three spent shell casings in the takeout area," said Small.
The victim was rushed to an area hospital where he later died.
A motive for the shooting is still under investigation.
Police say one person is in custody but it's still unclear if the individual is responsible for the homicide.
Anyone with information is asked to call police at 215-686-TIPS