The teen has been identified as Teryn Johnson.
It happened just before 9 p.m. Sunday near the 5300 block of Horrocks Street.
According to police, Johnson was walking with another teenage girl and a small dog to the 7-Eleven near Bridge and Large streets.
After leaving the store, they were making their way to one of their homes when the teens noticed men inside a gray Dodge Challenger.
At some point, the teens made eye contact with the men in the vehicle but no words were exchanged, police said.
Teen shot, killed while walking dog in Frankford: Police
Police say the teens noticed the car was following them.
When they got to the 5300 block of Horrocks Street, police say a suspect inside the car fired at least six shots striking Johnson multiple times.
The teen was rushed to Temple University Hospital where she later died. The other teenager was not injured.
Police are trying to determine if the teens knew the suspects.
"The victims did not indicate that they knew the individuals, in fact no words were exchanged, so it's unclear for what reason they were targeted, if they were targeted at all," Pace said.
No arrests have been made.
Anyone with information is asked to call police at 215-686-TIPS.