Police say it appears the home she was in may have been targeted.
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Police say they aren't sure yet if the woman who was shot and killed was the intended target, but they say whoever is responsible focused all of the shots on the house where she was located.
Investigators say 911 calls came in just before 1:30 a.m. about gunshots along the 3900 block of Melon Street in the city's Mantua section.
Police believe there was a shootout between people inside the home and people outside.
First responders say they found a woman, who is believed to be in her mid-30s, dead on the living room floor with a gunshot wound to the head.
It is not clear if the gunshot that hit her in the head came from inside or outside the home.
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"We know at least eight shots were fired from two separate caliber semi-automatic weapons. Many of these shell casings appear to be rifle rounds and several other of the spent shell casings appear to come from a semi-automatic handgun," said Chief Inspector Scott Small, with the Philadelphia Police Department.
Homicide detectives were speaking with witnesses and working to review surveillance video on the street.
The shooting remains under investigation.
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